Beginning with the structure, types, functions, and gene organization of antibodies, the book aims to shine a detailed light on the monoclonal antibodies (often referred to as mAbs) that have revolutionized the fields of therapeutics and diagnostics.The book describes the different ways of generating chimeric, humanized, and fully human monoclonal antibodies, emphasizing phage display, hybridoma, and rDNA technology. In addition, the book focuses on the various recombinant antibody formats in detail:Drug conjugates: Antibody-drug conjugates (ADCs), Immunotoxins (Recombinant, Humanized and Fully Human) and Antibody-antibiotic conjugate (AAC)Bispecific antibodies: scFv based (BiTE, DARTs and TandAbs) and Full-length IgG basedAbzymes and Antibody-directed enzyme prodrug therapy (ADEPT)Fc-fusion proteinsSingle-domain antibodies (VHH and IgNAR sdAb)The book discusses the various therapeutic applications of monoclonal antibodies, along with the immunogenicity issues. The book also covers the modes of administration and side effects of monoclonal antibodies, along with the challenges and issues faced while developing a monoclonal antibody into a therapeutic agent. Modifications introduced by the researchers to decrease the immunogenicity issues and increase the efficacy of therapeutic mAbs are also described.The book is an invaluable resource for researchers and students in biology and medicine, biotechnology, immunology, genetics, molecular biology, and anyone interested in antibody engineering.
✔ Author(s): Roohi Bansal
✔ Title: Antibodies and their role in therapeutics: Monoclonal Antibodies | Immunology | Biotechnology (Biotechnology Books)
✔ Rating : 4.4 out of 5 base on (15 reviews)
✔ ISBN-10: 9355781601
✔ Language: English
✔ Format ebook: PDF, EPUB, Kindle, Audio, HTML and MOBI
✔ Device compatibles: Android, iOS, PC and Amazon Kindle
Readers' opinions about Antibodies and their role in therapeutics by Roohi Bansal
Cedrica Ingram
Experience the profound impact of art and creativity in this beautifully written novel. The author's evocative writing and compelling characters bring the story to life. Each chapter explores the transformative power of art with sensitivity and depth. The plot is both thought-provoking and emotionally resonant. It's a narrative that celebrates the beauty of human expression. Ideal for readers who appreciate stories about art and inspiration.
Nayeli Hooper
Uncover the secrets of a haunted mansion in this chilling gothic novel. The author's atmospheric writing and suspenseful plot make for a captivating read. Each character's hidden motives and dark pasts add to the tension. The twists and surprises keep you guessing until the very end. It's a haunting and immersive story that you won't want to put down. Perfect for fans of gothic fiction.
Hailie King
Discover the inspiring story of a trailblazer who changed the world in this compelling biography. The author's detailed research and engaging writing bring the subject to life. Each chapter reveals new insights into the person's life and achievements. The narrative is both informative and deeply moving, offering valuable life lessons. It's a story that motivates and inspires. Perfect for history buffs and biography enthusiasts.
