It isn't easy to be a phage. First, what is a phage? A phage is a virus that infects Bacteria. To succeed, a phage must encounter, recognize, and enter a particular type of bacterial cell, then coerce it to make more phages rather than more cells. Of course, the cell resists this hostile takeover in numerous ways, all of which the successful phage overcomes. The triumphant phage then proceeds with its replicative business. In this engaging book, Merry Youle relates some of the tactics used by 21 pheatured phages to outwit their host and successfully maintain their own lineage generation after generation.This ongoing contest of wits is a matter of life and death for both players. A phage chromosome arriving in its intended host cell is met by the cell's state-of-the-art defenses. Unless it dodges or neutralizes every one, it will be chopped into a nutritious snack for the cell. If the phage survives, it then quickly diverts the cell's machinery to production of more phages, rather than more cells. Under skillful phage supervision, manufacture of phage components proceeds at top speed, with all parts produced when needed and in the quantities required. As the pieces come off the assembly line, they self-assemble into sophisticated transport packages, each carrying a phage chromosome and capable of delivering it into a new host cell. When a new crop of progeny is ready - perhaps 25, 100, or more of them - the phage ruptures the cell to free them all and send them out into the world in quest of hosts of their own. Overall, a balance is maintained so that both the phages and their hosts thrive.Many phages have the option to instead follow a different script. When they arrive in a host, they can opt to delay immediate hostile takeover and to instead form a coalition with the host for mutual benefit. In this case, as the cell grows and divides, the phage is replicated and inherited by both daughter cells. This can continue for many generations. However, if the cell encounters life-threatening difficulties, the phage ends the alliance and switches to rapid replication. Cell rupture and release of the new generation follows quickly.Each step of the way presents challenges that test the ingenuity of the phages. In this book, tales of phage prowess are accompanied by pertinent electron micrographs; every chapter is enlivened by informative illustrations created by San Diego fine artist Leah Pantéa. The writing focuses on strategies and underlying principles, with a minimum of jargon. Since some knowledge of molecular biology is required to appreciate phage wizardry, a primer of the needed basics is provided for those unfamiliar with that subject. Thus, these phage adventures can be enjoyed by a wide audience.Despite being the most abundant life form, the phages - being much smaller than even the microbes they infect - elude our everyday perception. Thinking Like a Phage offers a tour of this unseen dimension of life on Earth. Whether you are an expert or new to the phage world, these vignettes drawn from phage life will intrigue you. Awareness of this vast, creative, yet invisible realm can enrich your appreciation for the living world of which we, as Homo sapiens, are only a small part.
✔ Author(s): Merry Youle,Leah Pantéa
✔ Title: Thinking Like a Phage: The Genius of the Viruses That Infect Bacteria and Archaea
✔ Rating : 4.6 out of 5 base on (47 reviews)
✔ ISBN-10: 0990494314
✔ Language: English
✔ Format ebook: PDF, EPUB, Kindle, Audio, HTML and MOBI
✔ Device compatibles: Android, iOS, PC and Amazon Kindle
Readers' opinions about Thinking Like a Phage by Merry Youle
Aleena Tran
Experience a heartwarming journey of self-discovery and love in this beautifully written novel. The protagonist's struggles and triumphs are portrayed with incredible empathy. Richly developed characters and a compelling plot make the story unforgettable. The emotional depth of the narrative resonates long after the book is closed. It's a touching tale that celebrates the human spirit. Perfect for readers seeking an uplifting read.
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Follow the heartwarming journey of a group of friends navigating life's challenges together. The author's empathetic writing and well-developed characters create a deeply emotional experience. Each chapter explores themes of friendship, love, and resilience with sensitivity. The plot's twists and turns keep you engaged throughout. It's a story that celebrates the bonds that connect us. Perfect for readers who enjoy stories about friendship and community.
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Discover the inspiring story of a trailblazer who changed the world in this compelling biography. The author's detailed research and engaging writing bring the subject to life. Each chapter reveals new insights into the person's life and achievements. The narrative is both informative and deeply moving, offering valuable life lessons. It's a story that motivates and inspires. Perfect for history buffs and biography enthusiasts.
