Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. Careful dissection of molecular mechanisms of action of ARB against HCV and the Ebola virus revealed that ARB blocked viral entry. ARB might, therefore, constitute a pharmacological approach against globally prevalent viruses, and an affordable molecule for emerging countries in urgent need for effective antiviral therapies.
✔ Author(s): Eve-Isabelle Pécheur,Stephen J. Polyak
✔ Title: Arbidol: an antiviral against globally prevalent viruses: A promising antiviral strategy
✔ Rating : 2.6 out of 5 base on (76 reviews)
✔ ISBN-10: 3639653467
✔ Language: English
✔ Format ebook: PDF, EPUB, Kindle, Audio, HTML and MOBI
✔ Device compatibles: Android, iOS, PC and Amazon Kindle
Readers' opinions about Arbidol by Eve-Isabelle Pécheur
Audriana Daly
Follow the gripping tale of a detective unraveling a complex web of crime and corruption. The author's detailed writing and intricate plotting make for a suspenseful read. Each clue and revelation adds to the tension, keeping you on the edge of your seat. The characters are well-developed, with motivations that feel real and compelling. The climax delivers a satisfying resolution to the mystery. A must-read for thriller enthusiasts.
Poppy Brooks
Unravel the secrets of a small town with a dark past in this gripping thriller. The author's atmospheric writing and suspenseful plot make for a page-turner. Each character's hidden motives and secrets add to the tension. The twists and surprises keep you guessing until the very end. It's a chilling and captivating read that you won't want to put down. Perfect for fans of mystery and suspense.
Elvenia Connolly
Follow the heartwarming journey of a group of friends navigating life's challenges together. The author's empathetic writing and well-developed characters create a deeply emotional experience. Each chapter explores themes of friendship, love, and resilience with sensitivity. The plot's twists and turns keep you engaged throughout. It's a story that celebrates the bonds that connect us. Perfect for readers who enjoy stories about friendship and community.
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